De novo design of a biologically active amyloid.

On solving possibilistic multi- objective De Novo linear programming

Multi-objective De Novo linear programming (MODNLP) is problem for designing optimal system by reshaping the feasible set (Fiala [3] ). This paper deals with MODNLP having possibilistic objective functions coefficients. The problem is considered by inserting possibilistic data in the objective functions coefficients. The solution of the problem is defined and established under the using of effi...

Microbial Contamination of Leafy Vegetables in Porto-Novo, Republic of Benin

Background: The vegetables provide important nutrients to human beings. Nevertheless, contaminated vegetables can cause health problems because of their microbial load. The aim of this study was to assess the microbial quality of three main leafy vegetables cultivated and consumed at Porto-Novo in Republic of Benin. Methods: Totally, 36 samples of amaranth, nightshade, and lettuce were taken f...

A de novo Reciprocal X; 9 Translocation in A Patient with Premature Ovarian Failure

A method for probing the mutational landscape of amyloid structure

MOTIVATION Proteins of all kinds can self-assemble into highly ordered β-sheet aggregates known as amyloid fibrils, important both biologically and clinically. However, the specific molecular structure of a fibril can vary dramatically depending on sequence and environmental conditions, and mutations can drastically alter amyloid function and pathogenicity. Experimental structure determination ...

Design, Synthesis, And Evaluation Of Molecular Inhibitors For Biologically Relevant Enzymes

St. John, Sarah Emma. Ph.D., Purdue University, December 2013. Design, Synthesis, and Evaluation of Molecular Inhibitors for Biologically Relevant Enzymes. Major Professor: Mark A. Lipton. The work in this thesis details the design, synthesis, and biological evaluation of molecular inhibitors for the inhibition of biologically relevant enzymes. The first three chapters of this thesis concern th...